The bus station Tachovske namesti (line 207, 133) is just a 100m from the hotel, 2 stops to city centre.
From Airport:
Bus 119 from airport to stop - Dejvicka, than metro (line A):
from Dejvicka to Staromestska (3 stops), than switch to bus 133 from Staromestska to Tachovske namesti. And by walk (50m from hotel)