By Ttrain:
From the Saint Jean SNCF train station, take the tramway line C and get off at Quinconces, The Hotel des 4 Soeurs is 20 metres away, just after the Tourist Office.
By Plane:
From Bordeaux/Mérignac airport, you can take the Jet bus shuttle. It runs every 20 minutes and stops at the Tourist Office, 20 metres from the hotel.