If You come by car: From Lisbon take the auto route A1, you will take the arrow that says Torres Novas/Abrantes(A23), then take the road to Portalegre (IP2), you will past Alpalhão and then turn to Castelo de Vide (all the trip has a total of 221 Km).
From Algarve take the A2 to Évora, then take the IP2 to Portalegre at last take the N521 to Castelo de Vide.
If you come BY PLANE: From Lisbon airport take a taxi to gare do Oriente railway station, from there take a train to Castelo de Vide.